Open Access Highly Accessed Research article

Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects

Dominik Lutter1,2*, Carsten Marr1, Jan Krumsiek1, Elmar W Lang2 and Fabian J Theis1,3*

1 Institute of Bioinformatics and Systems Biology, CMB, Helmholtz Zentrum München, Germany

2 CIML Group, Institute of Biophysics, University of Regensburg, 93040 Regensburg, Germany

3 Max Planck Institute for Dynamics and Self-Organisation, Bunsenstrasse 10, D-37073 Göttingen, Germany

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BMC Genomics 2010, 11:224 doi:10.1186/1471-2164-11-224

Published: 6 April 2010

Additional files

Additional file 1:

Intragenic microRNAs. Table of all inragenic miRNAs and corresponding host genes used in this analysis. The table lists the miRNA name, gene symbol and miRNA locus in tab delimited columns.

Format: CSV Size: 3KB Download file

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Additional file 2:

host gene cluster. Table of all identified host gene clusters. Each row lists one host gene cluster with cluster identifier and the list of comma separated host gene symbols. The cluster identifier is composed of the dataset identifier as used in the manuscript and numbering in Roman numbers.

Format: CSV Size: 1KB Download file

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Additional file 3:

Supplementary Figures A, B, and C. (A) Heatmap of the Ago ternary map based Odz4 target genes and the corresponding Correlation Coefficients (B). (C) Z-scores for all annotated host genes based on the Pictar and consensus model target gene predictions.

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