Table 1

Comparison of the zebra finch, chicken, human, and mouse degradomes

Gene

Zebra finch

Chicken

Human

Mouse


Apoptosis

Caspase-1, -4, -5, -12

Not found

Only caspase-1

All

All

Caspase-17

Not found

Present

Absent

Absent

Caspase-18

Present

Present

Absent

Absent

Host defense

Granzyme K

Absent

Absent

Present

Present

Neutrophil elastase

Absent

Absent

Present

Present

Complement factor D

Absent

Absent

Present

Present

Azurocidin

Absent

Absent

Present

Absent

Proteinase 3

Absent

Absent

Present

Present

Granzymes B and H, cathepsin G, chymase

Granzyme Z and Z-like

Granzyme Z

All

All

PRSS33

Absent

Absent

Present

Present

Tryptases

Absent

Absent

Present

Present

Haptoglobins

Absent

Absent

Two

One

Cathepsin F

Absent

Absent

Present

Present

Cathepsin W

Absent

Absent

Present

Present

PRSS16

Absent

Absent

Present

Present

Paracaspase

Triplicated

Triplicated

Present

Present

Legumain-2

Absent

Absent

Present

Present

Tissue development

Enamelysin

Absent

Absent

Present

Present

Kallikrein-4

Absent

Absent

Present

Present

MMP-7, -8, -19, -21, -23B, -25

Absent

Absent

Present

Present

MMP-26

Absent

Absent

Present

Absent

ADAMTS-4

Absent

Absent

Present

Present

Reproduction

Alpha-aspartyl dipeptidase

Present

Present

Absent

Absent

Nothepsin

Present

Present

Absent

Absent

ADAMTS-16

Absent

Absent

Present

Present

Testins

Absent

Absent

Present

Present

ADAM3B, -4,-4B,-5,-6

Absent

Absent

Pseudogenes

Present

ADAM7

Absent

Absent

Present

Present

ADAM30

Absent

Absent

Present

Present

Acrosin

Expanded

Present

Present

Present

Prolactin-induced protein

Absent

Absent

Present

Present

Ovastacin

Absent

Absent

Present

Present

ISP1

Absent

Absent

Absent

Present

ISP2

Absent

Absent

Pseudogene

Present

Choryolytic enzymes

Present

Present

Absent

Absent

Neural development

Caspase-3

Duplicated

Present

Present

Present

Neurotrypsin

Duplicated

Duplicated

Present

Present

Bace

Duplicated

Present

Present

Present

Presenilin homolog-2

Absent

Absent

Present

Present

Transmembrane serine protease 5

Absent

Present

Present

Present

Brain serine protease-2

Absent

Absent

Present

Present

Other

Pepsinogen A

Duplicated

Duplicated

Triplicated

Present

Pepsinogen C

Not found

Present

Present

Present

ADAMTS-13

Duplicated

Present

Present

Present

Tubulointerstitial nephritis antigen-like 1

Absent

Absent

Present

Present

Desert hedgehog protein

Absent

Absent

Present

Present

Sentrin-3

Absent

Absent

Present

Present

Autophagin-4

Absent

Absent

Present

Present

NAALADASE like 1

Absent

Absent

Present

Present

Transferrin receptor 2

Absent

Absent

Present

Present

Dipeptidyl-peptidase 3

Absent

Absent

Present

Present

Vitellogenic-like carboxypeptidase

Absent

Absent

Present

Present

ClpP caseinolytic peptidase

Absent

Absent

Present

Present

Abhydrolase domain containing 4

Absent

Absent

Present

Present

Polyserases

One

One

Three

Three

Kallikreins

Absent

Absent

Present

Present

Ubiquitin-specific protease-11

Absent

Absent

Present

Present


Quesada et al. BMC Genomics 2010 11:220   doi:10.1186/1471-2164-11-220

Open Data