Table 5

Frequent individual elements from TFBS modules in proximal promoter regions of the 8q24.3 ZNF genes a

TFBS familyb

Individual TFBSb

Factorc

ZNF7

ZNF16

ZNF34

ZNF250

ZNF251

ZNF252

ZNF517

Total

Promoter countd


AP2F

AP2.02

AP-2α

2

0

0

1

1

1

2

7

5


EGRF

EGR1.02

EGR1

3

0

1

2

2

1

1

10

6


ETSF

CETS1 P54.01

c-ETS1 (p54)

1

0

0

0

0

1

1

3

3

ELK1.02

ELK1

1

4

0

0

3

1

0

9

4

SPI1_ PU1.02

SPI1

0

0

1

2

2

3

1

9

5


IKRS

IK2.01

IKZF1

1

0

0

0

1

1

1

4

4


SP1F

SP1.01

SP1

3

1

1

4

3

3

3

18

7

SP1.03

SP1

2

0

0

3

3

3

1

12

5


Total

13

5

3

12

15

14

10

72


a Only TFBS module families that occur in promoter regions of at least three 8q24.3 ZNF genes served as input for counting. Listed are only TFBS that were found in at least three different promoter regions. The position in a module was not considered. It does not exlude the presence of additional binding sites within the promoter sequences.

b TFBS family and individual TFBS matrices based on Genomatix Matrix Library 8.1. Derived from the results using Genomatix ModelInspector. Detailed listing and sequences in Additional file 14

c Transcription factor recognizing the respective TFBS

d Number of 8q24.3 ZNF promoter regions with matches of a given TFBS

Lorenz et al. BMC Genomics 2010 11:206   doi:10.1186/1471-2164-11-206

Open Data