Figure 4.

Patterns of pathway regulation. (A) A schematic of reciprocal correlation of metabolic and signaling pathways in mammalian transcription. (B) Relation of major KEGG pathways to OXPHOS. The directional regulation of 14 major KEGG pathways (number of up- minus down-regulated genes in a given KEGG pathway normalized to the total number of regulated genes within a study) was color-coded with yellow and blue representing low and high expression of the pathways, respectively. The cellular pathways of "protein export", "cell cycle" and ubiquitin-mediated proteolysis" were positively correlated with OXPHOS, while "calcium-mediated signaling", and structural components important for cell-cell contact (e.g. "cell adhesion molecules", "tight junctions", "gap junctions", "adherens junctions") were negatively correlated with OXPHOS.