Correlation of KEGG pathway gene expression. There is a positive correlation between OXPHOS and TCA ('citrate') cycle (A) and between the KEGG pathways of OXPHOS and proteasome (B). OXPHOS and MAPK signaling pathways are negatively correlated (C), while signaling pathways (e.g. JAK-STAT and MAPK) are positively correlated to each other (D). Plots represent net direction of regulation of a KEGG pathway, i.e. number of up- minus down-regulated genes in relation to the total number of regulated genes within a study. Correlation plots include all 64 animal and human myocardial microarray studies listed in Additional File 2.
Barth et al. BMC Genomics 2010 11:197 doi:10.1186/1471-2164-11-197