Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis
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* Corresponding author: Ian Dunham dunham@ebi.ac.uk
BMC Genomics 2010, 11:175 doi:10.1186/1471-2164-11-175
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Commentary
Hidden reach of the micromanagers Peter S Linsley, Aimee L Jackson BMC Biology 2010, 8:53 (11 May 2010) Discussing the implications of a recent BMC Genomics study, Linsley and Jackson consider why “off-target” micro RNA-like effects of small interfering RNAs can predominate in functional genomic screens.
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