Open Access Highly Accessed Research article

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

Paul W O'Toole1*, William J Snelling2, Carlos Canchaya3, Brian M Forde1, Kim R Hardie4, Christine Josenhans5, Robert LJ Graham2, Geoff McMullan2, Julian Parkhill6, Eugenio Belda67 and Stephen D Bentley6

Author Affiliations

1 Department of Microbiology, & Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

2 School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry, BT52 1SA, N. Ireland, UK

3 Department of Biochemistry, Genetics and Immunology, University of Vigo, 36310 Vigo, Spain

4 School of Molecular Medical Sciences, University of Nottingham, Centre for Biomolecular Sciences, Nottingham NG7 2RH, UK

5 Hannover Medical School, Department for Medical Microbiology and Hospital Epidemiology, Hannover, Germany

6 Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK

7 Current Address:Cavanilles Institute of Biodiversity and Evolutionary Biology, Department of Genetics, University of Valencia, Valencia, Spain

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BMC Genomics 2010, 11:164  doi:10.1186/1471-2164-11-164

Published: 10 March 2010

Additional files

Additional file 1:

Autotransporter loci in the H. mustelae genome.

Format: DOCX Size: 179KB Download file

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Additional file 2:

Blood group antigen-associated genes in the genome sequence of H. mustelae, and compared with H. pylori

Format: DOCX Size: 13KB Download file

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Additional file 3:

Motility- and flagellum-associated genes in the genome sequence of H. mustelae, and compared with H. pylori

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Additional file 4:

Protein secretion-associated genes in the genome sequence of H. mustelae, and compared with H. pylori

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Additional file 5:

Presence of homopolyeric tracts within/between H. mustelae genes, and homopolymer length variation in sequence data

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Additional file 6:

The envelope proteome of H. mustelae determined by LC-MS.

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Additional file 7:

The cytosolic proteome of H. mustelae determined by LC-MS

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Additional file 8:

Motifs associated with highly expressed genes in the H. mustelae cell envelope proteome

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Additional file 9:

Motifs associated with highly expressed genes in the H. mustelae cytosol proteome

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Additional file 10:

Orthologue comparisons between selected Campylobacterales, and T. maritima as out-group. The lower triangle indicates the total number of orthologs in genome-genome comparisons while the upper triangle shows the average sequence identity values expressed in percentages.

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Additional file 11:

Presence in H. mustelae of orthologues of H. pylori genes identified as essential for colonization of the Mongolian gerbil.

Format: DOCX Size: 16KB Download file

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