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Open Access Highly Accessed Research article

Unified translation repression mechanism for microRNAs and upstream AUGs

Subramanian S Ajay15, Brian D Athey23 and Inhan Lee24*

Author Affiliations

1 Bioinformatics Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA

2 Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA

3 Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109, USA

4 miRcore, 2929 Plymouth Rd, Ann Arbor, MI 48105, USA

5 Current address: Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

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BMC Genomics 2010, 11:155  doi:10.1186/1471-2164-11-155

Published: 5 March 2010

Additional files

Additional file 1:

Genes containing uAUGs that do/do not interact with 3'-ends of conserved miRNAs. GO-term analysis for two categories of genes that contain uAUGs. The first category consists of genes with uAUGs that are predicted to interact with 3'-ends of conserved miRNAs (likely targets). The second category of genes contains uAUGs but shows no such interactions.

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Open Data

Additional file 2:

Predicted interactions between uAUG 6 and 7 (Table 5) of KLF9 and conserved miRNAs. uAUG6 and uAUG7 are thought to be responsible for limiting translation of KLF9 in HeLa cells but not in N2A. Predicted binding between both ends of conserved miRNAs in Table 5 and the two uAUGs are shown.

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Open Data