Table 8

Analysis of communication pathways for mature B-cells (B-cells)

Gene expressed in MatureB

Mean Intensity

Corresponding gene in stroma

Mean Intensity

NIH3T3

Osteoblasts


chemokine (C-X-C motif) receptor 4

1275

chemokine (C-X-C motif) ligand 12

12222

23

798

epidermal growth factor receptor

145

Epiregulin

422

288

153

interleukin 2 receptor, gamma chain

2746

interleukin 7

189

92

255

Integrin alpha 4

1640

junction adhesion molecule 2

201

16

26

integrin beta 1 (fibronectin receptor beta)

235

junction adhesion molecule 2

201

16

26

integrin beta 2

1781

junction adhesion molecule 3

152

42

204

lymphotoxin A

540

lymphotoxin B receptor

965

285

519

transforming growth factor, beta 1

718

Similar to Ornithine decarboxylase (ODC)

197

146

14

epidermal growth factor receptor

145

transforming growth factor alpha

261

13

21

transforming growth factor, beta 1

718

transforming growth factor, beta receptor II

171

85

253

transforming growth factor, beta 1

718

transforming growth factor, beta receptor III

3653

3429

1152

lymphotoxin A

540

tumor necrosis factor receptor superfamily, member 1a

1974

959

1143

lymphotoxin A

540

tumor necrosis factor receptor superfamily, member 1b

108

721

108

Integrin alpha 4

1640

vascular cell adhesion molecule 1

692

182

929

integrin beta 1 (fibronectin receptor beta)

235

vascular cell adhesion molecule 1

692

182

929

integrin beta 7

942

vascular cell adhesion molecule 1

692

182

929


Tables 1, 2, 3, 4, 5, 6, 7 and 8. Receptor ligand pairs identified as possible means of communication between a model stroma cell line OP9 and sorted hematopoietic cells from the mouse bone marrow. Expression values observed in fibroblastic NIH3T3 and osteoblastic MC3T3 cells are included to allow for the identification of stromal cell specific interactions. The diagram only display receptor ligand pairs were genes on the hematopoietic array as well as of the stromal cells arrays have a normalized expression value above 100. Full lists of potential interactions can be found in Additional files 2, 3, 4, 5, 6, 7, 8 and 9. For sorted cells as well as OP9 the value is a mean out of 2 experiments for complete list of genes for each cell type see Additional files 2, 3, 4, 5, 6, 7, 8 and 9.

Zetterblad et al. BMC Genomics 2010 11:108   doi:10.1186/1471-2164-11-108

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