This article is part of the supplement: Eighth International Conference on Bioinformatics (InCoB2009): Computational Biology
Proceedings
Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors
Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, PR China
BMC Genomics 2009, 10(Suppl 3):S31 doi:10.1186/1471-2164-10-S3-S31
Published: 3 December 2009Additional files
Additional file 1:
Top 39 common compounds. The following 39 common compounds were excluded from the compound conversion and metabolic inhibitory networks: i) 28 which take part in more than 100 reactions; ii) 4 which are too general, i.e. RNA, DNA, protein and peptide; and iii) the remaining 7 were energy metabolism-related nucleoside monophosphates, nucleoside diphosphates and nucleoside triphosphates.
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Additional file 2:
Branch points curated from KEGG pathways. The 132 branch points in human liver are shown in Additional file 2.
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Additional file 3:
Rate-limiting enzymes from the literature. The curated 96 rate-limiting enzymes from human liver are listed in Additional file 3.
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