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This article is part of the supplement: Eighth International Conference on Bioinformatics (InCoB2009): Computational Biology

Open Access Proceedings

Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors

Min Zhao and Hong Qu*

Author Affiliations

Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, PR China

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BMC Genomics 2009, 10(Suppl 3):S31  doi:10.1186/1471-2164-10-S3-S31

Published: 3 December 2009

Additional files

Additional file 1:

Top 39 common compounds. The following 39 common compounds were excluded from the compound conversion and metabolic inhibitory networks: i) 28 which take part in more than 100 reactions; ii) 4 which are too general, i.e. RNA, DNA, protein and peptide; and iii) the remaining 7 were energy metabolism-related nucleoside monophosphates, nucleoside diphosphates and nucleoside triphosphates.

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Additional file 2:

Branch points curated from KEGG pathways. The 132 branch points in human liver are shown in Additional file 2.

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Additional file 3:

Rate-limiting enzymes from the literature. The curated 96 rate-limiting enzymes from human liver are listed in Additional file 3.

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