Table 4

Cholesterol biosynthesis pathway. This table lists the proteins that are the constituents of the cholesterol biosynthesis pathway (Figure 5E). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

Uniprot id

Gene description

Gene Symbol

Properties


Q01581

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

HMGCS1

siRNA protein

Q03426

mevalonate kinase

MVK

None

Q14534

squalene epoxidase

SQLE

Known drug target

P48449

lanosterol synthase (2 3-oxidosqualene-lanosterol cyclase)

LSS

Known drug target

Q15126

phosphomevalonate kinase

PMVK

None

P53602

mevalonate (diphospho) decarboxylase

MVD

None

O95749

geranylgeranyl diphosphate synthase 1

GGPS1

None

P37268

farnesyl-diphosphate farnesyltransferase 1

FDFT1

HIV-1 target according to predictions


Balakrishnan et al. BMC Genomics 2009 10(Suppl 3):S30   doi:10.1186/1471-2164-10-S3-S30

Open Data