Table 3

Proteins in EGFR downregulation pathway. This table lists the proteins that are the constituents of the EGFR downregulation pathway (Figure 5D). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

Uniprot id

Gene description

Gene Symbol

Properties


O94973

adaptor-related protein complex 2 alpha 2 subunit

AP2A2

HIV-1 target according to Group1, predictions and the experts

Q96B97

SH3-domain kinase binding protein 1

SH3KBP1

HIV-1 target according to predictions

P09496

clathrin light chain (Lca)

CLTA

siRNA protein

P22681

Cas-Br-M (murine) ecotropic retroviral transforming sequence

CBL

HIV-1 target according to Group 2 and predictions

Q9UBC2

epidermal growth factor receptor pathway substrate 15-like 1

EPS15L1

None

P01133

epidermal growth factor (beta-urogastrone)

EGF

HIV-1 target according to Group 1 and predictions, siRNA protein and known drug target

P62993

growth factor receptor-bound protein 2

GRB2

HIV-1 target according to Group 2 and predictions, known drug target

Q00610

clathrin heavy chain (Hc)

CLTC

HIV-1 target according to Group 1 and predictions

Q9Y6I3

epsin 1

EPN1

None

O95782

adaptor-related protein complex 2 alpha 1 subunit

AP2A1

HIV-1 target according to Group 1, predictions and experts

Q99962

SH3-domain GRB2-like 2

SH3GL2

None

P42566

epidermal growth factor receptor pathway substrate 15

EPS15

HIV-1 target according to predictions

P00533

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog avian)

EGFR

HIV-1 target according to Group 2, and predictions, siRNA protein and known drug target

O14964

hepatocyte growth factor-regulated tyrosine kinase substrate

HGS

HIV-1 target according to Group 2, siRNA protein

P60953

cell division cycle 42 (GTP binding protein 25 kDa)

CDC42

HIV-1 target according to Group 1 and predictions

P62988

ribosomal protein S27a

RPS27A

HIV-1 target according to Group 1, predications and experts, known drug target

O43597

sprouty homolog 2 (Drosophila)

SPRY2

None


Balakrishnan et al. BMC Genomics 2009 10(Suppl 3):S30   doi:10.1186/1471-2164-10-S3-S30

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