Table 2

Proteins in generation of the second messenger molecules pathway. This table lists the proteins that are the constituents of the generation of the second messengers pathway (Figure 3 and 4). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

Uniprot id

Gene description

Gene Symbol

Properties


P07766

CD3e molecule epsilon (CD3-TCR complex)

CD3E

HIV-1 target according to Group 1, Group 2 and predictions, known drug target

Q13094

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

LCP2

HIV-1 target according to predictions, siRNA protein

P04234

CD3d molecule delta (CD3-TCR complex)

CD3D

HIV-1 target according to Group 1, Group 2 and predictions

P19174

phospholipase C gamma 1

PLCG1

HIV-1 target according to Group 2, and predictions

O43561

linker for activation of T cells

LAT

None

O75791

GRB2-related adaptor protein 2

GRAP2

None

P01730

CD4 molecule

CD4

HIV-1 target according to Group 1, Group 2, predictions, and experts, siRNA protein

P09693

CD3g molecule gamma (CD3-TCR complex)

CD3G

HIV-1 target according to Group 1, Group 2, and predictions

P43403

zeta-chain (TCR) associated protein kinase 70kDa

ZAP70

HIV-1 target according to Group 1, Group 2, and predictions, known drug target

Q08881

IL2-inducible T-cell kinase

ITK

Known drug target

P06239

lymphocyte-specific protein tyrosine kinase

LCK

HIV-1 target according to Group 1, Group 2, and predictions

P20963

CD247 molecule

CD247

HIV-1 target according to Group 1, predictions and experts


Balakrishnan et al. BMC Genomics 2009 10(Suppl 3):S30   doi:10.1186/1471-2164-10-S3-S30

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