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Open Access Research article

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

Melissa Paoloni1*, Sean Davis2, Susan Lana3, Stephen Withrow3, Luca Sangiorgi4, Piero Picci4, Stephen Hewitt5, Timothy Triche6, Paul Meltzer2 and Chand Khanna1

Author Affiliations

1 Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

2 Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

3 Animal Cancer Center, Veterinary Teaching Hospital Colorado State University, Fort Collins, CO, 80523, USA

4 The Rizzoli Orthopedic Institute, Laboratory of Oncologic Research Bologna, Bologna 40136, Italy

5 Tissue Array Research Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

6 The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, 90027, USA

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BMC Genomics 2009, 10:625  doi:10.1186/1471-2164-10-625

Published: 23 December 2009

Additional files

Additional file 1:

Supplementary Data. Supplementary figure 1. Expression Intensity of IL8 and SLC1A3 in Human Osteosarcoma. Illustrates the protein expression intensity of IL-8 and SLC1A3 in a human osteosarcoma data set via TMA (primary biopsy, definitive resection and metastatic patients samples). Supplementary Table 1. Patient Information for Testing Set of Outcome linked Human Osteosarcoma Expression Data. Describes the patient information for the outcome linked human osteosarcoma expression data set (TT) used to define prognosis for our dog-like genes.

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