Table 2

Molecular dates estimated for the TMRCA and founder of Malagasy haplogroups M23, M23a and M23b from coding region information.

Coding Region nt577-nt16022

Synonymous Mutations


Haplogroup

n

ρ

σ

Mutation rate

TMRCA

95% CI

Founder age

95% CI

ρ

σ

Mutation rate

TMRCA

95% CI

Founder age

95% CI


M23

5

1.8

0.6

(1)

9,300

3,200-15,300

65,800

49,700-81,900

1.2

0.49

(2)

8,100

1,600-14,600

62,200

44,200-80,200

1.2

0.49

(3)

9,400

1,900-17,000

72,500

51,500-93,500

M23a

1

2

1.41

(1)

10,300

0-24,400

1

1

(2)

6,800

0-20,000

1

1

(3)

7,600

0-23,300

M23b

4

0.75

0.43

(1)

3,900

0-8,200

0.25

0.25

(2)

1,700

0-5,000

0.25

0.25

(3)

2,000

0-5,800


Mutation rate references: (1) One substitution per 5,139 years [56]; (2) One synonymous transition per 6,764 years [36]; (3) One synonymous mutation (transition or transversion) per 7,884 years [35]. Founder Age: ρ = 12,8; σ = 1.6 with the Mishmar and colleagues approach [56], and ρ = 9.2; σ = 1.36 with the Kivisild and colleagues [36] and Soares and colleagues [35] approaches. TMRCA, 95% confidence intervals (CI), and founder age are given in years.

Ricaut et al. BMC Genomics 2009 10:605   doi:10.1186/1471-2164-10-605

Open Data