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Open Access Research article

Correlation of microsynteny conservation and disease gene distribution in mammalian genomes

Simon C Lovell3, Xiting Li13, Nimmi R Weerasinghe23 and Kathryn E Hentges3*

Author Affiliations

1 Hangzhou Centre for Diseases Prevention and Control, Wulin Road No.277, Hangzhou 310006 PR China

2 College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK

3 Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT UK

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BMC Genomics 2009, 10:521  doi:10.1186/1471-2164-10-521

Published: 12 November 2009

Abstract

Background

With the completion of the whole genome sequence for many organisms, investigations into genomic structure have revealed that gene distribution is variable, and that genes with similar function or expression are located within clusters. This clustering suggests that there are evolutionary constraints that determine genome architecture. However, as most of the evidence for constraints on genome evolution comes from studies on yeast, it is unclear how much of this prior work can be extrapolated to mammalian genomes. Therefore, in this work we wished to examine the constraints on regions of the mammalian genome containing conserved gene clusters.

Results

We first identified regions of the mouse genome with microsynteny conservation by comparing gene arrangement in the mouse genome to the human, rat, and dog genomes. We then asked if any particular gene types were found preferentially in conserved regions. We found a significant correlation between conserved microsynteny and the density of mouse orthologs of human disease genes, suggesting that disease genes are clustered in genomic regions of increased microsynteny conservation.

Conclusion

The correlation between microsynteny conservation and disease gene locations indicates that regions of the mouse genome with microsynteny conservation may contain undiscovered human disease genes. This study not only demonstrates that gene function constrains mammalian genome organization, but also identifies regions of the mouse genome that can be experimentally examined to produce mouse models of human disease.