Table 3

Selected targets

CI

YPTB Locus

Definition

50-90 Cluster ID

Total non-pathogens

Total pathogens

Pathogen strains


0.01

2410

Magnesium transport ATPase mgtB

1035

3

8

Bme, Bma, Bp

0.03

2913

Deoxyribopyrimidine photolyase phrB

2801

0

6

Vc

0.06

2705

Putative manganese transport protein mntH

1611

3

8

Ba, Bma, Bp

0.12

3827

Outer membrane biogenesis protein

2798

0

5

-

0.13

0181

Putative protohaeme IX biogenesis protein hemY

3642

0

5

-

0.16

0756

Superoxide dismutase C sodC

1306

0

9

Bme, Cb, Ft, Vc

0.39

1340

Lysine specific permease cadR

563

2

9

Ba, Bma, Bp, Ft

0.42

0242

Glycerophosphoryl diester phosphodiesterase glpQ

2411

0

7

Bma, Bp

0.45

2699

Hypothetical protein

3924

0

7

Bma, Bp

0.76

1424

Hypothetical protein

1031

3

9

Bma, Bp, Ft, Vc

0.87

3166

Thiol:disulphide interchange protein dscB

3283

0

5

-

2.38

0188

Frataxin-like protein cyaY

2139

2

6

Vc

3.15

3505

Stringent starvation protein sspB

1207

3

7

Cb, Vc

ND

1167

Phosphate starvation protein

3911

0

6

-

ND

1251

Ecotin

3380

0

6

-

ND

2026

MviN-like protein

1296

3

9

Bma, Bp, Cb

ND

2995

Putative surface antigen

2296

2

7

Vc


Virulence-associated genes identified by computational methods and selected for experimental screening. These targets have been ranked by their competitive index (CI) value in Y. pseudotuberculosis. The CI value shown is the mean of the CI calculated from 3 spleens individually plated in triplicate. The top six candidates are deemed virulence-related by our experimental criteria. Hits to pathogens include all five members of the Enterobacteriaceae (Ec, Se, Sf, St, Yp) plus the additional strains listed using abbreviations from Table 1.

Stubben et al. BMC Genomics 2009 10:501   doi:10.1186/1471-2164-10-501

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