Table 1

Gene targets of tunicamycin identified in the tiling array experiment.

ORF

Gene Name

GO Biological Process

tunicamycin treatment relevance


YJR105W

ADO1

purine base metabolic process

knockout sensitive to tunicamycin [23]


YBR243C

ALG7

protein amino acid N-linked glycosylation and others

known target of tunicamycin [15-17]


YJL095W

BCK1

endoplasmic reticulum unfolded protein response and others

knockout sensitive [21-23], overexpressor resistant [21] to tunicamycin


YDL145C

COP1

ER to Golgi vesicle-mediated transport and others

involved in ER to Golgi vesicle-mediated transport [25]


YGR196C

FYV8

unknown

knockout sensitive to tunicamycin [21]


YER083C

GET2

protein insertion into ER membrane and others

knockout sensitive to tunicamycin [24]


YFL031W

HAC1

specific RNA polymerase II transcription factor activity and others

knockout sensitive to tunicamycin [21,23]


YHR079C

IRE1

endoplasmic reticulum unfolded protein response and others

knockout sensitive to tunicamycin [21,23]


YOR246C

N/A

unknown

unknown


YFL032W

N/A

unknown

likely deletes HAC1 promoter [19]


YER010C

N/A

unknown

interacts with kinases Ptk2, Tpk1 [30]


YMR308C

PSE1

protein import into nucleus and others

interacts with Ulp1, regulating ubiquitination [31]


YBR002C

RER2

ER to Golgi vesicle-mediated transport and others

involved in ER to Golgi vesicle-mediated transport [26]


YFR051C

RET2

ER to Golgi vesicle-mediated transport and others

interacts with Bre5, Hsc82, Hsp92 [31-33] which are involved in protein processing


YNL151C

RPC31

transcription from RNA polymerase III promoter

interacts with Mms1, Shp1, Ubi4, regulating ubiquitination [34,35]


YJR102C

VPS25

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway and others

involved in ubiquitin-dependent protein catabolism [36]


Ammar et al. BMC Genomics 2009 10:471   doi:10.1186/1471-2164-10-471

Open Data