Table 1

Panel of genes targeted by siRNA

siRNA

Affymetrix Transcript ID

Refseq ID

Gene description

Relevance to IFNγ response


Casp4

6986649

NM_007609

Caspase 4, apoptosis-related cysteine peptidase

pro-apoptotic, IFNγ induced

Ifi47

6780707

NM_010999

Interferon gamma inducible protein 47

IFNγ inducible protein

Ifnb1

6923147

NM_010510

Interferon beta 1, fibroblast

IFNγ induced, regulates immune signalling

Irf3

6960326

NM_016849

Interferon regulatory factor 3

virus-induced transcription factor, activates IFNα, & IFNβ

Irf5

6945011

NM_012057

Interferon regulatory factor 5

IFNγ induced, transcription factor, activates IFNα, IFNβ and plays a role in antiviral immunity & apoptosis

Lyn

6911337

NM_001111096

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

tyrosine kinase activity

Nfkb2

6870063

NM_019408

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2

DNA-binding sub-unit of NFkB transcription factor complex, regulates immune signalling

Sod2

6858344

NM_013671

Superoxide dismutase 2, mitochondrial

role in mitochondrial oxidative phosphorylation

Stat1

6749376

NM_009283

Signal transducer and activator of transcription 1

IFNγ-induced transcription factor, modulates IFN responses through signal transduction

Stat2

6771641

NM_019963

Signal transducer and activator of transcription 2

transcription factor, modulates IFN responses through signal transduction

Traf1

6886021

NM_009421

Tnf receptor-associated factor 1

mediates anti-apoptotic signals from TNF receptors


Lacaze et al. BMC Genomics 2009 10:372   doi:10.1186/1471-2164-10-372

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