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Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty

Mark S Longo, Dawn M Carone, NISC Comparative Sequencing Program, Eric D Green, Michael J O'Neill and Rachel J O'Neill*

BMC Genomics 2009, 10:334 doi:10.1186/1471-2164-10-334

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Comparative genomics reveals birth and death of fragile regions in mammalian evolution

Max A Alekseyev, Pavel A Pevzner Genome Biology 2010, 11:R117 (30 November 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A new model explains the frequencies of breakpoints at genomic rearrangement hotspots by demonstrating that fragile sites undergo birth and death.

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The where and wherefore of evolutionary breakpoints

David Sankoff Journal of Biology 2009, 8:66 (24 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

David Sankoff discusses the properties of chromatin in breakpoint regions and their relevance to evolutionary change in the light of two recent papers in BMC Genomics.

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