Table 1

Tabulation of S. aureus essential genes by category.

Category

Number of essential genes in S. aureus

Number of S. aureus essential genes with an essential orthologue in B. subtilis

Number of B. subtilis essential genes with no essential orthologue in S. aureus


DNA metabolism

27

22

3

DNA replication

16

16

0

DNA packaging and segregation

11

6

3


RNA metabolism

25

14

2

Basic transcription machinery

4

4

0

RNA modification

10

7

2

RNA regulation

11

3

0


Protein synthesis

102

86

7

Ribosomal proteins

49

47

4

tRNA synthetase

22

20

1

tRNA modification

2

2

0

Translation factors

13

10

1

Protein folding

5

2

0

Protein modification

3

0

0

Protein translocation

8

5

1


Cell envelope

66

43

22

Lipids

15

11

0

Phospholipids

4

4

1

Cell wall/amino sugar

3

3

3

Diaminopimelate biosynthesis

0

0

4

Peptidoglycan biosynthesis

17

10

2

Teichoic acid biosynthesis

12

8

0

Cell division

12

7

0

Cell shape

0

0

3

Na/H transporter

0

0

9

Cell envelope – other

3

0

0


Carbon metabolism

20

9

0

Glycolysis

11

9

0

Pentose phosphate

4

0

0

Intermediary metabolism

3

0

0

Regulation

2

0

0


Respiratory pathways

11

4

9

Isoprenoid/Mevalonate biosynthesis

8

1

2

Menaquinone biosynthesis

1

1

7

Thioredoxin

2

2

0


Nucleotides

12

8

2

Purine biosynthesis

3

2

2

Purine metabolism

1

0

0

Purine/Pyrimidine biosynthesis

3

3

0

Pyrimidine biosynthesis

5

3

0


Cofactors

24

13

2

Acetyl CoA/CoA

5

1

0

Folate

6

1

2

NAD biosynthesis

4

4

0

SAM

1

1

0

Fe-sulphate cluster

7

6

0

Riboflavin biosynthesis

1

0

0


Other/unknown

64

14

2

Amino acid transporter

1

0

0

GTP binding

6

6

0

Other

4

3

1

Unknown

53

5

1


Chaudhuri et al. BMC Genomics 2009 10:291   doi:10.1186/1471-2164-10-291

Open Data