Figure 2.

Transcription profile analysis of the significant differentially expressed genes in P. berghei infected vs. non infected hepatoma cells. (A) Hierarchical clustering using Euclidean distances for both samples (column, expressed as mean of replicates) and genes (probesets) showing differential expression (B stat > 0, FC >1.5×). (B) Principal component analysis (PCA) of transcript profiles from infected and non-infected Hepa1-6 cells. The plot shows simplified dataset structure of the significant differentially expressed probesets and clearly groups the samples in a 3-dimensional space between infected and non-infected cells but also along Plasmodium developmental time. Black, red, green and blue dots represent infected cells at 6, 12, 18 and 24 h p.i. respectively, while turquoise, pink, yellow and grey dots represent non-infected cells at 6, 12, 18 and 24 h p.i.