Figure 3.

FISH panel of HSA, GGO e PTR chromosomes. Partial metaphases showing the chromosomal localization of the human DDX11L1 gene and of its orthologs on human, chimpanzee, and gorilla metaphases, determined by fluorescence in situ hybridization analysis. (A), (B) and (C) localization of the DDX11L specific probe on Homo sapiens (HSA), common chimpanzee, Pan troglodytes (PTR), and Gorilla gorilla (GGO) chromosomes, respectively. For an easy comparison of the results, the phylogenetic nomenclature was used. The asterisks indicate the DDX11L gene family members not present in the Human Genome Project final release (NCBI Build 36.1). Examples of polymorphic rearrangments detected on human chromosomes are underlined (2, 9, and X). Note that chimpanzee and gorilla have large blocks of very telomeric, complex heterochromatic sequences [39]. The DDX11L signals appear to map centromerically with respect to these blocks.

Costa et al. BMC Genomics 2009 10:250   doi:10.1186/1471-2164-10-250
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