Table 5

Expression levels and interindividual differences of currently known macular disease genes with RPE expression[26].

gene symbol

Genbank accession

mean intensity μint (perc)

CV (perc)


high interindividual variation (CV > 10th perc)


CFB

NM_001710

10,382

(94)

215

(99)


C3

NM_000064

9,910

(94)

145

(98)


FBLN5

NM_006329

2,823

(76)

136

(98)


PRPH2

NM_000322

32,204

(98)

86

(93)


GUCA1B

NM_002098

2,329

(72)

83

(93)


CST3

NM_000099

338

(26)

79

(92)


CFH

NM_000186

8,508

(92)

77

(91)


TIMP3

NM_000362

7,209

(91)

73

(90)


intermediate interindividual variation (CV 10th – 90th perc)


C2

NM_000063

1,689

(65)

71

(90)


BEST1

NM_004183

132,611

(99)

58

(84)


HTRA1

NM_002775

45,420

(99)

47

(74)


EFEMP1

NM_004105

20,292

(97)

44

(70)


C1QTNF5

NM_015645

23,226

(98)

40

(64)


TLR4

NM_003266

225

(45)

38

(60)


low interindividual variation (CV < 90th perc)


none

-

-

-


Data are grouped by coefficient of variation (CV) in descending order into three groups, high CV (> 90th percentile, CV > 72), intermediate (CV 10th – 90th percentile) and low CV (< 10th percentile, CV < 19). Perc: percentile.

Booij et al. BMC Genomics 2009 10:164   doi:10.1186/1471-2164-10-164

Open Data