Table 1

Overrepresented Kegg pathways in macular RPE expressed genes with high, moderate and low expression levels and high or low levels of interindividual variability (coefficient of variation, CV).

expression level

all expression levels

high (> 90th perc)

moderate (50th–90th perc)

low (10th–50th perc)

all CV

ecm-receptor interaction (E)

oxidative phosphorylation (B,E)

ribosome (B,E)

ATP synthesis (B,E)

phosphatidylinositol signaling system (B,E)

aminosugars metabolism (E)

neuroactive ligand receptor interaction (B,E)

long-term depression (E)

o-glycan biosynthesis (E)

calcium signaling pathway (E)


high CV

type I diabetes mellitus (B,E)

focal adhesion (B,E)

cytokine-cytokine receptor interaction (E)

complement and coagulation cascades (E)

antigen processing and presentation (E)

ecm-receptor interaction (E)

antigen processing and presentation (B,E)

complement and coagulation cascades (E)

focal adhesion (E)

cytokine-cytokine receptor interaction (E)

type I diabetes mellitus (E)

low CV


glycosaminoglycan degradation (E)



Overrepresented pathways were identified with B: a Benjamini-Hochberg corrected p value < 0.001, or E: an Ease score p value < 0.001. Perc: percentile, high CV: > 90th percentile, low CV: < 10th percentile.

Booij et al. BMC Genomics 2009 10:164   doi:10.1186/1471-2164-10-164

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