Table 1

A list of 20 most regulated annotated genes during vitellogenesis and after E2 treatment of males.

Description

Symbol

GeneBank

Vit4/NV

Vit2/NV

E/M

Function according to http://www.ncbi.nlm.nih.gov/sites/entrez webcite gene


1

Vitellogenin 3, phosvitinless

vtg3

AF254638

103.3

94.5

125.7

Egg yolk precursor, phosvitinless.

2

Similar to reticulon 1

rtn1

BI983061

75.5

88.5

79.3

Associates with the endoplasmic reticulum.

3

Nothepsin, cathepsin e

nots

AJ278269

76.6

76.8

86.8

Eukaryotic aspartyl (acid) protease.

4

Similar to low density lipoprotein receptor

ldlr

BF717943

28.3

28.2

136.3

Plays a central role in cholesterol metabolism.

5

Moderately similar to spectrin repeat containing, nuclear envelope 1

syne1

AW019847

16.1

21.2

14.7

Involved in cytoskeletal structure.

6

Similar to ectonucleoside triphosphate diphosphohydrolase 4

entpd4

AW344063

97

70.2

25.5

Cleaving nucleotide tri- and diphosphates.

7

Similar to follistatin-like 1

fstl1

AI884233

NS

NS

3.2

Play an important role in tissue specific regulation.

8

Similar to human Prefoldin subunit 6

pfdn6

BI891290

1.5

NS

3.7

Binds and stabilizes newly synthesized polypeptides.

9

Lag1 homolog, ceramide synthase 2

lass2

AW171063

1.8

NS

4.5

May play a role in the regulation of cell growth.

10

Ankyrin repeat domain 6

ank

AF395113

12.3

10.3

4.3

Ankyrin repeats mediate protein-protein interactions.

11

Similar to nitric oxide synthase interacting protein

nosip

AI545274

8.1

7.4

11.6

Promotes translocation of eNOS from the plasma membrane to intracellular sites.

12

Similar to heterogeneous nuclear ribonucleoprotein h1

hnrnph1

AI497414

1.7

NS

2.8

RNA recognition/binding motif.

13

Similar to family with sequence similarity 46 c

fam46c

AI959558

4.5

4.7

14

The function of this gene is unknown.

14

Vitellogenin 1

vtg1

AF406784

7

6.3

28.6

Egg yolk precursor.

15

Similar to human guanylate binding protein1

gbp1

BM181499

8.5

8.2

2.7

Specifically bind guanine nucleotides (GMP, GDP, and GTP).

16

Similar to human protein fam20c precursor?

fam20c

BF717944

33.2

35.2

20.8

Has a crucial role in normal bone development.

17

Similar to glutamate receptor, ionotropic, kainate 1

grik1

BM071695

NS

NS

-16.4

Ligand-gated ion channel.

18

Similar to lectin, mannose-binding, 1 precursor

lman1

AW175541

4.8

4

6.6

Mannose-specific lectin, a member of a Mannose-specific lectin, a member of a the secretory pathway of animal cells.

19

Similar to rna polymerase ii associated protein 1

rpap1

BM157210

NS

NS

2.4

The function of this gene is unknown.

20

Estrogen receptor 1

esr1

AF349412

16

15.5

17

A ligand-activated transcription factor.


Regulation during vitellogenesis is indicated as the ratio between Vit4/NV and Vit2/NV.

Regulation by E2 is indicated by the ratio E/M. A weak similarity is indicated by a question mark (?). For the complete list of the regulated genes see Additional file 1.

Levi et al. BMC Genomics 2009 10:141   doi:10.1186/1471-2164-10-141

Open Data