Figure 1.

The core connections in the InR/TOR network. Regulatory connections through phosphorylation are shown in brown and through direct transcriptional regulation in blue. Arrows indicate activating interactions and bars inhibitory relationships. Correlation coefficients between genes are shown in blue for males and in red for females, with significant measures italicized; if there was no genetic variation for a particular gene, then the correlation could not be calculated and this is indicated by a '?'.