An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions

doi:10.1186/1471-2164-10-100

BMC Genomics

Volume 10

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Uchida S
Schneider A
Wiesnet M
Jungblut B
Zarjitskaya P
Jenniches K
Kreymborg Kg
Seeger W
Braun T

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Uchida S
Schneider A
Wiesnet M
Jungblut B
Zarjitskaya P
Jenniches K
Kreymborg Kg
Seeger W
Braun T
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Research article

An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions

Shizuka Uchida¹^* , André Schneider¹^* , Marion Wiesnet¹ , Benno Jungblut¹ , Polina Zarjitskaya¹ , Katharina Jenniches¹ , Karsten grosse Kreymborg¹^,2 , Werner Seeger¹^,2 and Thomas Braun¹

¹Max-Planck-Institute for Heart and Lung Research, Parkstr. 1, 61231 Bad Nauheim, Germany

²University of Giessen Lung Center (UGLC), Medical Clinic II and V, Justus-Liebig-University Giessen, Klinikstrasse 36, 35392 Giessen, Germany

author email corresponding author email* Contributed equally

BMC Genomics 2009, 10:100doi:10.1186/1471-2164-10-100


Published:	6 March 2009

Additional files

Additional file 1:

Coverage of GO terms by genes that matched the applied selection criteria. For each organism, the percentage coverage was derived by dividing the number of genes obtained (numerator in the parenthesis) by the number of genes that are classified under a specific GO term (denominator in the parenthesis). Fisher's exact test was applied to each GO coverage.

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Additional file 2:

Combinatorial GO annotations of mouse genes categorized under "heart development". 43 genes that are categorized under "heart development (GO:0007507)" were obtained. Gene symbols, GeneIDs, and combinations of organisms, in which they were selected, are indicated.

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Additional file 3:

Venn diagrams for brain-, liver-, spleen-, and testis-enriched genes. The numbers of tissue-enriched genes selected for the top 20% in the ranking of UniGene tissue expression profiles are shown for the 4 organisms analyzed and displayed as combinations of these organisms. In each combination, the number of genes with less than 2 articles after MeSH term filtering for the corresponding tissue is shown in parenthesis. (A) brain-enriched genes; (B) liver-enriched genes; (C) spleen-enriched genes; and (D) testis-enriched genes.

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Additional file 4:

GO coverage for brain-, liver-, and spleen-enriched genes. For each organism, the percentage coverage of the GO term for "development" of the corresponding tissue was derived by dividing the number of genes obtained (numerator in the parenthesis) by the number of genes that are classified under a specific GO term (denominator in the parenthesis). Fisher's exact test was applied to each GO coverage. In the case of "testis-enriched genes", there is no GO term for "testis development".

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Additional file 5:

List of datasets used in this study. List of datasets used in this study.

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