Research article

Mapping of the Mouse Actin Capping Protein Beta Subunit Gene

Marilyn C Hart² , Yulia O Korshunova³ and John A Cooper¹

¹  Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA

²  Winona State University, Winona, MN 55987, USA

³  Department of Genetics, Washington University, St. Louis, MO 63110, USA

author email corresponding author email

BMC Genomics 2000, 1:1doi:10.1186/1471-2164-1-1

Published:	27 July 2000

Abstract

Background

Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have three isoforms of CPβ produced by alternatively splicing from one gene; lower organisms have one gene and one isoform.

Results

We isolated genomic clones corresponding to the β subunit of mouse CP and identified its chromosomal location by interspecies backcross mapping.

Conclusions

The CPβ gene (Cappb1) mapped to Chromosome 4 between Cdc42 and D4Mit312. Three mouse mutations, snubnose, curly tail, and cribriform degeneration, map in the vicinity of the β gene.