Table 1

Summary of TDR analysis for binary genotypes and covariates

Approach
Model
 Include Z
 Stratify by Z
 Residualize by Z
 Ignore Z
1. ADDITIVE
 +/+
 +/+
 +/+
 +/+
2. ADDITIVE WITH CONFOUNDING
 ++/+
 +/+
 +/+
 ++/++
3. ADDITIVE WITH EFFECT MEDIATOR
 - -/- -
 - -/- -
 - -/- -
 -/-
4. INTERACTION WITH MAIN EFFECTS
 ++/++
 ++/++
 ++/++
 ++/++
5. INTERACTION WITH NO MAIN EFFECTS
 +/++
 +/++
 -/+
 -/+
6. CONDITIONAL ASSOCIATION
 +/+
 +/+
 -/+
 -/+

Summary of simulation results in Figures 1 and 2: Results are given in pairs corresponding to RF and MARS respectively; a "+" indicates reasonable TDR (≥ 80%) for detecting moderate effect sizes (≥ 0.5); "++" indicates reasonable TDR (≥ 80%) for detecting small effect sizes (≥ 0.3);"-" indicates lower TDR (50% to 80%) for moderate effect sizes; and '--" indicates very low TDR (< 20%) at moderate effect sizes. Correlation between X1 and Z is fixed at 0.5 for MODEL 2.

Nonyane and Foulkes BMC Genetics 2008 9:71   doi:10.1186/1471-2156-9-71