Table 3 |
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|
Mean ± SEM for anthropometric measures, body composition, and serum lipid profile of study subjects stratified according to LAMA5 rs659822 or rs944895 genotype and ethnicity. |
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|
European American |
African American |
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|
|
|
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|
rs659822 |
C/C |
C/T |
T/T |
P* |
C/C |
C/T |
T/T |
P |
|
|
||||||||
|
n |
13 |
42 |
46 |
29 |
69 |
29 |
||
|
BMI |
26.8 ± 0.5 |
27.6 ± 0.3 |
27.7 ± 0.3 |
0.1 |
28.2 ± 0.4 |
27.2 ± 0.3 |
27.4 ± 0.4 |
0.3 |
|
Height (cm) |
162.6 ± 1.2 |
164.6 ± 0.8 |
167.3 ± 1.1 |
0.02 |
164.9 ± 1.2 |
164.1 ± 0.8 |
162.5 ± 1.4 |
0.2 |
|
Weight (kg) |
69.8 ± 2.3 |
74.7 ± 1.3 |
78.2 ± 1.4 |
0.008 |
76.5 ± 1.7 |
73.2 ± 1.1 |
71.9 ± 1.5 |
0.05 |
|
Total fat mass (kg) |
28.8 ± 1.9 |
31.5 ± 1.0 |
33.7 ± 1.0 |
0.01 |
31.3 ± 1.2 |
30.3 ± 0.9 |
29.4 ± 1.1 |
0.3 |
|
Lean tissue mass (kg) |
37.6 ± 0.8 |
39.9 ± 0.5 |
41.2 ± 0.5 |
0.003 |
41.4 ± 0.8 |
39.5 ± 0.5 |
38.7 ± 0.8 |
0.03 |
|
Triacylglycerol (mg/dl) |
104.9 ± 11.5 |
120.5 ± 11.4 |
112.9 ± 6.3 |
0.8 |
68.1 ± 4.7 |
65.8 ± 3.2 |
70.3 ± 4.3 |
0.6 |
|
Total cholesterol (mg/dl) |
153.4 ± 6.3 |
163.0 ± 4.9 |
159.6 ± 4.9 |
0.8 |
162.3 ± 6.5 |
150.1 ± 3.8 |
163.1 ± 6.9 |
0.6 |
|
HDL-cholesterol (mg/dl) |
42.4 ± 2.4 |
36.0 ± 1.6 |
34.5 ± 1.1 |
0.003a |
46.1 ± 1.8 |
41.2 ± 1.3 |
45.2 ± 2.1 |
0.07a |
|
LDL-cholesterol (mg/dl) |
90.0 ± 5.8 |
102.9 ± 4.1 |
102.5 ± 4.1 |
0.5 |
102.7 ± 6.2 |
95.8 ± 3.6 |
103.8 ± 6.4 |
0.9 |
|
rs944895 |
||||||||
|
n |
9 |
50 |
42 |
28 |
66 |
33 |
||
|
BMI |
26.6 ± 0.7 |
27.5 ± 0.3 |
27.8 ± 0.3 |
0.3 |
27.8 ± 0.4 |
27.6 ± 0.3 |
27.1 ± 0.4 |
0.5 |
|
Height (cm) |
163.1 ± 1.2 |
165.6 ± 1.0 |
166.0 ± 0.9 |
0.3 |
163.9 ± 1.4 |
164.4 ± 0.8 |
163.1 ± 1.2 |
0.6 |
|
Weight (kg) |
70.9 ± 2.8 |
75.5 ± 1.3 |
76.9 ± 1.3 |
0.09 |
73.5 ± 1.4 |
74.5 ± 1.2 |
72.1 ± 1.6 |
0.7 |
|
Total fat mass (kg) |
28.2 ± 2.1 |
31.7 ± 1.0 |
33.3 ± 1.0 |
0.1 |
29.9 ± 1.1 |
30.7 ± 0.9 |
29.7 ± 1.2 |
0.5 |
|
Lean tissue mass (kg) |
38.5 ± 1.1 |
40.5 ± 0.6 |
40.2 ± 0.5 |
0.7 |
40.0 ± 0.8 |
40.2 ± 0.5 |
38.8 ± 0.9 |
0.4 |
|
Triacylglycerol (mg/dl) |
101.8 ± 8.6 |
117.3 ± 9.2 |
115.2 ± 8.1 |
0.9 |
78.9 ± 5.1 |
65.7 ± 3.1 |
60.9 ± 4.0 |
0.02 |
|
Total cholesterol (mg/dl) |
159.8 ± 7.5 |
161.2 ± 4.6 |
159.2 ± 4.9 |
0.7 |
156.5 ± 5.6 |
159.4 ± 4.2 |
148.3 ± 6.5 |
0.7 |
|
HDL-cholesterol (mg/dl) |
41.2 ± 3.1 |
35.1 ± 1.4 |
36.3 ± 1.3 |
0.5b |
43.4 ± 2.1 |
45.2 ± 1.4 |
39.1 ± 1.5 |
0.03b |
|
LDL-cholesterol (mg/dl) |
98.2 ± 8.6 |
102.7 ± 3.8 |
99.8 ± 4.1 |
0.7 |
97.4 ± 5.1 |
101.1 ± 4.0 |
97.0 ± 6.1 |
1 |
|
|
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|
* P values represent the significance of the comparison among genotypes. P values without subscript were calculated assuming additive models. P values with subscripts (a) and (b) were calculated assuming recessive and dominant models, respectively. P values significant after permutations tests to correct for multiple comparisons are highlighted in bold case |
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|
De Luca et al. BMC Genetics 2008 9:52 doi:10.1186/1471-2156-9-52 |
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