Research article
Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice
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* Corresponding author: Juan F Medrano jfmedrano@ucdavis.edu
1 Department of Animal Science, University of California, Davis, One Shields Ave., Davis, CA 95616-8521, USA
2 Department of Biochemistry and Molecular Biology, Louisiana State University Health, Sciences Center, and Children's Hospital Research Institute, New Orleans, LA 70112-2223, USA
3 Department of Medicine, Division of Cardiology, University of, California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095-1679, USA
4 Research Center for Human Natural Defense System, Yonsei, University College of Medicine, Seoul, 120-752, Korea
5 Department of Anatomy and Neurobiology, University of, Maryland Medical School, 20 Penn St, Baltimore, MS 21201, USA
BMC Genetics 2008, 9:34 doi:10.1186/1471-2156-9-34
Published: 25 April 2008Additional files
Additional file 1:
Differentially expressed genes in HG2DF2 non-recombinant F2 mice. These data represent a list of genes differentially expressed in HG2DF2 non-recombinant F2 mice determined using DNA microarrays.
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Additional file 2:
Scg5 whole brain expression is up-regulated in HG versus B6 male mice at 3, 4.5 and 9 weeks of age and the Scg5 promoter contains two tandem putative Stat5b DNA binding sites. Expression analysis of Scg5 as a function of HG genotype.
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Additional file 3:
Scg5 haplotypes based on available SNP data. Haplotype analysis of Scg5 in "low" and "high" expressing strains using publically available SNP data.
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Additional file 4:
Hierarchical clustering analysis of Scg5 haplotype blocks. Illustrates the relationships of Scg5 haplotype blocks in "low" and "high" expressing strains.
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Additional file 5:
Scg5 promoter sequencing primers. List of PCR primers used for Scg5 sequencing.
Format: PDF Size: 11KB Download file
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