Figure 1.

Short circuit current measurements in the epithelia of the upper respiratory tract (A, B, n = 4 per mouse line), ileum (C, D, n = 4) and colon epithelium (E, n = 10) in inbred Cftr^{TgH(neoim)Hgu} mouse strains and their cognate wild type controls. ΔIsc represents the change in short circuit current from baseline after addition of either amiloride (A), forskolin (B), forskolin + genistein (D) and carbachol (C, E). * P < 0.05; ** P < 0.01; *** P < 0.001.