Additional file 3.

A 2-dimensional histogram showing the distribution of regression slope along with the distribution of natural log-transformed intensity. Natural log-transformed normalized (as described in Methods) intensity of 80,000 randomly selected chromosome X probes of a representative set of 1X–5X samples and natural log-transformed copy number were used to calculate the regression slope. The black vertical line denotes the maximum log intensity ratio and the green vertical line denotes the top 8% log intensity, above which there are few probes with high regression slopes. The top 10% intensity is used as the cut-off threshold in the probe filtering process.

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Shen et al. BMC Genetics 2008 9:27   doi:10.1186/1471-2156-9-27