BMC Genetics

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Volume measures for linkage disequilibrium

Yuguo Chen1, Chia-Ho Lin2 and Chiara Sabatti2,3*

Author Affiliations

1 Department of Statistics, University of Illinois at Urbana-Champaign, Champaign IL 61820, USA

2 Department of Statistics, UCLA, Los Angeles CA 90095-1554, USA

3 Department of Human Genetics, UCLA, Los Angeles CA 90095-7088, USA

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BMC Genetics 2006, 7:54 doi:10.1186/1471-2156-7-54

Published: 17 November 2006

Additional files

Additional file 1:

Measures of disequilibrium between biallelic markers. This .pdf file contains a detailed description of measures of disequilibrium for population haplotype distributions for biallelic markers. We recall the definition of D' and R2 as well of Dvol and Mvol. We graphically illustrate the difference in normalization procedure between all of these measures. This makes it easy to see the identity of D' and Dvol when the population haplotype frequency is known.

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