Table 1 |
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|
MOD scores and estimated trait-model parameters for microsatellites and SNPsa |
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|
Penetrancesc |
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|
|
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|
Chromosome |
Positionb |
MOD |
f+/+ |
fm/+ |
f+/m |
fm/m |
p |
|
|
|
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|
Microsatellites |
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|
1 |
140.3 |
5.93 |
Male |
0.0080 |
0.0100 |
0.0080 |
0.1000 |
0.050 |
|
D1S1631 |
Female |
0.1000 |
0.9500 |
0.9500 |
0.9500 |
|||
|
2 |
135.9 |
4.34 |
Male |
0.0450 |
0.0600 |
0.0450 |
0.4900 |
0.008 |
|
D2S1328 |
Female |
0.0350 |
0.3900 |
1.0000 |
1.0000 |
|||
|
7 |
20.7 |
2.94 |
Male |
0.0450 |
0.1000 |
0.0450 |
0.2500 |
0.010 |
|
D7S1790 |
Female |
0.0500 |
0.5400 |
0.0500 |
1.0000 |
|||
|
7 |
122.3 |
2.46 |
Male |
0.0008 |
0.0020 |
0.0008 |
0.0080 |
0.500 |
|
D7S1799 |
Female |
0.0000 |
0.0000 |
0.0000 |
0.3400 |
|||
|
10 |
61.3 |
3.73 |
Male |
0.0000 |
0.5500 |
0.5100 |
1.0000 |
0.240 |
|
D10S1426 |
Female |
0.0000 |
0.0000 |
0.1600 |
0.1600 |
|||
|
12 |
171.6 |
3.68 |
Male |
0.0600 |
0.1500 |
0.2100 |
0.2300 |
0.020 |
|
D12S1045 |
Female |
0.1300 |
0.5100 |
1.0000 |
1.0000 |
|||
|
13 |
37.6 |
2.73 |
Male |
0.0050 |
0.0050 |
0.0100 |
0.0100 |
4·10-5 |
|
D13S325 |
Female |
0.0150 |
0.1800 |
0.6600 |
1.0000 |
|||
|
15 |
126.6 |
3.67 |
Male |
0.0080 |
0.0080 |
0.0100 |
0.0100 |
0.920 |
|
D15S642 |
Female |
0.1100 |
0.1100 |
1.0000 |
1.0000 |
|||
|
21 |
38.0 |
3.86 |
Male |
0.0000 |
0.0500 |
0.0900 |
0.0900 |
0.390 |
|
D21S1440 |
Female |
0.0000 |
0.0000 |
0.1000 |
0.7400 |
|||
|
Affymetrix SNPs |
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|
1 |
150.0 |
4.10 |
Male |
0.0500 |
0.0500 |
0.0500 |
0.3600 |
0.080 |
|
tsc0056040 |
Female |
0.0500 |
0.5600 |
0.8300 |
0.8300 |
|||
|
2 |
147.2 |
3.26 |
Male |
0.0450 |
0.1100 |
0.0450 |
0.2700 |
0.110 |
|
tsc1376918 |
Female |
0.1600 |
0.4300 |
1.0000 |
1.0000 |
|||
|
7 |
18.3 |
3.66 |
Male |
0.0250 |
0.1000 |
0.0800 |
0.1300 |
0.210 |
|
tsc0058614 |
Female |
0.0000 |
0.0150 |
0.0150 |
0.1100 |
|||
|
7 |
99.2 |
3.46 |
Male |
0.0000 |
0.0200 |
0.0000 |
0.0500 |
0.490 |
|
tsc0287517 |
Female |
0.0000 |
0.7400 |
0.0000 |
0.7400 |
|||
|
10 |
62.9 |
4.24 |
Male |
0.0000 |
0.0700 |
0.0700 |
0.1100 |
0.470 |
|
tsc0608195 |
Female |
0.0350 |
0.0350 |
0.8700 |
0.8700 |
|||
|
12 |
156.1 |
2.61 |
Male |
0.0450 |
0.0900 |
0.0450 |
0.6000 |
0.010 |
|
tsc0053128 |
Female |
0.0800 |
0.0800 |
0.5800 |
1.0000 |
|||
|
13 |
62.0 |
3.97 |
Male |
0.0500 |
0.0600 |
0.1100 |
0.1300 |
0.110 |
|
tsc0949707 |
Female |
0.1500 |
0.1500 |
1.0000 |
1.0000 |
|||
|
15 |
---d |
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|
21 |
---d |
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|
|
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|
a Genetic regions for which the analysis allowing for imprinting yielded a MOD score around or above 3.5 either for the microsatellites (sex-specific map) or the Affymetrix SNPs (sex-averaged map), together with the best-fitting parameters of the trait model. b The genetic positions of the highest MOD (given in cM, together with the marker closest to the peak) reflect different coordinates for the COGA microsatellite and Affymetrix SNP maps. Therefore, two results given at corresponding positions in the table for microsatellite and SNP markers most likely reflect the same linkage signal, despite possibly different genetic positions for the two marker sets. c +, the wild-type; m, mutant allele, with the paternally inherited allele listed first; p, the disease allele frequency. A trait model with fm/+ »f+/m points to maternal imprinting (i.e., paternal expression), whereas fm/+ «f+/m indicates paternal imprinting (i.e., maternal expression). d ---, In the two genetic regions on chromosomes 15 and 21 mentioned for the microsatellites, MOD scores were below 2 for the Affymetrix SNPs. |
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|
Strauch et al. BMC Genetics 2005 6(Suppl 1):S162 doi:10.1186/1471-2156-6-S1-S162 |
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