Table 3 |
||
|
Medline citations to genes showing altered expression in TH mice. |
||
|
Gene name |
Diabesity-relevant articles |
General function |
|
|
||
|
Genes chosen known to be involved in diabetes with expression change |
||
|
Alb1 |
5548 |
Lipid binding and carrier activity |
|
Leptin |
3170 |
Hormone activity |
|
Lpl |
775 |
Lipid catabolism or fatty acid metabolism |
|
Pparg |
702 |
Lipid metabolism and steroid hormone receptor activity |
|
Glut2 |
142 |
Glucose transport and carbohydrate metabolism |
|
Agpat2 |
5 |
Phospholipid biosynthesis |
|
ExQuest chosen genes with expression change, known or unknown to be involved in diabetes |
||
|
Col18a11 |
7 |
Potent antiangiogenic protein, structural molecule |
|
Vldlr2 |
7 |
Lipid transport |
|
Scp2 |
4 |
Sterol carrier activity, lipid binding, and steroid biosynthesis |
|
Fmo1 |
3 |
Electron transport and oxidoreductase activity |
|
Pnliprp2 |
1 |
Lipid catabolism |
|
KitL |
0 |
Signal transduction |
|
Igfbp2 |
0 |
Insulin-like growth factor binding |
|
Ela2 |
0 |
Proteolysis and peptidolysis |
|
Ela3b |
0 |
Proteolysis and peptidolysis, and cholesterol metabolism |
|
Gsta3 |
0 |
Biosynthesis of steroid hormones |
|
Agpat3 |
0 |
Phospholipid metabolism |
|
Hsd17b9 |
0 |
Steriod biosynthesis and oxidoreductase activity |
|
Decr2 |
0 |
Peroxisome organization and biogenesis, and oxidoreductase activity |
|
Tff3 |
0 |
Epithelium healing |
|
Pi4k2a |
0 |
Inositol/phosphatidlinositol kinase activity |
|
Functional summary of genes with expression changes3 |
||
|
Lipid related gene activity |
8 |
|
|
Hormone related gene activity |
6 |
|
|
Inflammation or response to injury |
4 |
|
|
Oxidoreductase activity |
3 |
|
|
Signal transduction |
3 |
|
|
Proteolysis and peptidolysis |
2 |
|
|
Carbohydrate related gene activity |
1 |
|
|
|
||
|
1Hsd17b9 medline search: there are 88 articles for the homolog "11-beta hydroxysteroid dehydrogenase", and 157 with "hydroxysteroid dehydrogenase". 2 Vldlr MEDLINE search: 4818 diabesity relevant articles found for Vldl. 3 Genes with dual functions are counted twice. |
||
|
Brown et al. BMC Genetics 2005 6:12 doi:10.1186/1471-2156-6-12 |
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