|
Number of main haplotypes observed within genes compared to the number of possible haplotypes and yin yang haplotype distribution |
|||||||
| Gene |
Chromosome location |
No. of SNPs |
Kb spanned |
SNP density (kb/SNP) |
Observed No. of haplotypesa |
Expected No. of haplotypes |
Yin Yang haplotypesb |
|
|
|||||||
| ApoE |
19q13.2 |
4 |
3 |
0.75 |
6 |
16 |
GATC, CGTC |
| COL1A1 |
17q21.3-q22 |
3 |
16 |
5.33 |
4 |
8 |
GGG, GTG |
| ER-α |
6q25.1 |
7 |
291 |
41.57 |
20 |
128 |
TCGCGGG, CTGCGGG |
| LEPR |
1p31.2 |
3 |
66 |
22 |
7 |
8 |
GCG, GGA |
| PTHR1 |
3p22-p21.1 |
4 |
9 |
2.25 |
7 |
16 |
GTAA, ACGC |
| TGF-β1 |
19q13.1 |
3 |
22 |
7.33 |
4 |
8 |
C+C, T+C- |
| UCP3 |
11q13.4 |
3 |
5 |
1.67 |
4 |
8 |
TCT, CTC |
| VDR |
12q12-14 |
4 |
39 |
9.75 |
12 |
16 |
GTGT, GTAC |
|
a: Only haplotypes with frequencies more than 1% were included [14] b: For the PTHR1 and UCP3, Yin yang haplotypes were presented. For the other six genes, the two most common haplotypes were presented. The haplotypes were reconstructed based on the SNPs in the order from 5' to 3' on the chromosome within each gene. | |||||||
Long et al. BMC Genetics 2004 5:11 doi:10.1186/1471-2156-5-11 |
|||||||