Pedigree and genotype errors in the Framingham Heart Study

doi:10.1186/1471-2156-4-S1-S41

BMC Genetics
Volume 4
Suppl 1

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This article is part of the supplement: Genetic Analysis Workshop 13: Analysis of Longitudinal Family Data for Complex Diseases and Related Risk Factors .

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Pedigree and genotype errors in the Framingham Heart Study

Gerry Brush and Laura Almasy

Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA

author email corresponding author email

BMC Genetics 2003, 4(Suppl 1):S41doi:10.1186/1471-2156-4-S1-S41


Published:	31 December 2003

Abstract

The pedigree and genotype data from the Framingham Heart Study were examined for errors. Errors in 21 of 329 pedigrees were detected with the program PREST, and of these the errors in 16 pedigrees were resolved. Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections. Double-recombinant errors were more common, with 142 being detected at mistyping probabilities of 0.25 or greater.