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This article is part of the supplement: Genetic Analysis Workshop 13: Analysis of Longitudinal Family Data for Complex Diseases and Related Risk Factors

Open Access Proceedings

An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression

Gyungah Jun, Yeunjoo Song, Catherine M Stein and Sudha K Iyengar*

Author Affiliations

Department of Epidemiology and Biostatistics, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, Ohio, USA

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BMC Genetics 2003, 4(Suppl 1):S8  doi:10.1186/1471-2156-4-S1-S8

Published: 31 December 2003

Abstract

A genome-wide screen was conducted for type 2 diabetes progression genes using measures of elevated fasting glucose levels as quantitative traits from the offspring enrolled in the Framingham Heart Study. We analyzed young (20–34 years) and old (≥ 35 years) subjects separately, using single-point and multipoint sibpair analysis, because of the possible differential impact of progression on the groups of interest. We observed significant linkage with change in fasting glucose levels on 1q25-32 (p = 5.21 × 10-8), 3p26.3-21.31 (p = 1 × 10-11), 8q23.1-24.13 (p = 2.94 × 10-6), 9p24.1-21.3 (p = 7 × 10-7), and 18p11.31-q22.1 (p < 10-11). The evidence for linkage on chromosomes 8 and 18 was consistent for the subset of study participants aged 43 through 55 years.

Keywords:
Type 2 diabetes; progression; longitudinal; genome-wide search; fasting glucose; model-free linkage analysis