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This article is part of the supplement: Genetic Analysis Workshop 13: Analysis of Longitudinal Family Data for Complex Diseases and Related Risk Factors

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Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study

Martyn C Byng1, Sheila A Fisher1*, Cathryn M Lewis1 and John C Whittaker2

Author Affiliations

1 Division of Genetics and Development, Guy's, King's and St. Thomas' School of Medicine, 8th Floor, Guy's Tower, Guy's Hospital, London, United Kingdom

2 Department of Epidemiology and Public Health, Imperial College School of Medicine, London, United Kingdom

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BMC Genetics 2003, 4(Suppl 1):S4  doi:10.1186/1471-2156-4-S1-S4

Published: 31 December 2003


We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.