Table 1

Clinical and histological findings in AKXD-28/Ty eyes.

Clin

Histo

Age

(months)

ISA

TRAN

DP

ISA

PAS

PS

RGCD

ONA

ONC

INL


6-8

0/12

12/12

0/12

0/8

0/8

0/8

0/8

0/8

0/1

0/8

12 per

9-14

52/78

78/78

0/78

2/8

7/8

6/8

2/8

0/4

0/3

0/8

36 mi

70 mi

2 mi

7 mi

4 mi

2 mib

16 mod

8 mo

2 mo

15-22

60/60 a

60/60 a

0/60 a

11/12

12/12

9/12

11/12

8/10

7/7

7/12

24 mi

20 mi

2 mi

4 mi

3 mi

1 mic

1 mic

1 moc

36 mo

40 mo

7 mo

4 mo

1 mo

10 sevd

3 mod

6 sevd

2 sev

4 sev

5 sev

4 sevd

23-28

26/26

26/26

1/26

25/25

23/23

24/25

25/25

23/23

21/21

24/25

26 sev

26 sev

25 sev

1 mi

2 mi

25 sev

1 mo

21 sev

15 mo

9 mo

22 sev

7 sev

13 sev


Clin = clinical, Histo = histological. a All were 15 months old; b All were 14 months old; cAll were 17 months old; dAll were 18 to 22 months old. Summary of Clinical and histological phenotypes in AKXD28 eyes. Clinical and histologic examinations were performed with different cohorts of mice. The age groups are arranged so that the overall prevalence and severity of specific disease features within each group are similar. In general, age groups are not skewed with mice of a particular age, except that the 15-22 month old group examined clinically consists of 15 month old mice. Mice less than 6 months old were characterized by normal clinical exams and histology but are not included in Table 1. The numerator indicates the number of eyes exhibiting the lesion, whereas the denominator indicates the number of eyes successfully analyzed for that lesion. The number of eyes with a finding of a specific severity is shown in italics. Phenotypes were ranked as peripheral (per), mild (mi), moderate (mo), or severe (sev) (see Materials and methods, and ref 11). Clinical abbreviations: iris stromal atrophy (ISA), iris transillumination (TRAN), and dispersed pigment (DP). Histologic abbreviations: iris stromal atrophy (ISA), peripheral anterior synechiae (PAS), posterior synechiae (PS), retinal ganglion cell depletion (RGCD), optic nerve atrophy (ONA), optic nerve cupping (ONC), and inner nuclear layer cell loss (INL). Other phenotypes not listed here include corneal neovascularization and corneal calcification that occurred in some mice, and cataracts whose incidence increased with age and that were present in all 23 month old or older mice. Despite gentle handling and great care, clinical examination induced subconjunctival hemorrhage in approximately 30-50% of AKXD28 mice. Though less frequent, spontaneous and handling induced vascular hemorrhage into the anterior chamber (hyphema) also was observed in a number of AKXD28 mice. These bleeding phenotypes occur only rarely in other strains we have studied.

Anderson et al. BMC Genetics 2001 2:1   doi:10.1186/1471-2156-2-1

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