Open Access Highly Accessed Research article

Association study of 15q14 and 15q25 with high myopia in the Han Chinese population

Yu Qiang1, Wenjin Li1, Qingzhong Wang1, Kuanjun He1, Zhiqiang Li1, Jianhua Chen12, Zhijian Song1, Jia Qu3, Xiangtian Zhou3, Shengying Qin1, Jiawei Shen1, Zujia Wen1, Jue Ji1 and Yongyong Shi145*

Author Affiliations

1 Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R China

2 Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R China

3 Wenzhou Medical College, Wenzhou 325003, P.R China

4 Shanghai Changning Mental Health Center, 299 Xiehe Road, Shanghai 200042, P.R China

5 Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai 200042, P.R China

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BMC Genetics 2014, 15:51  doi:10.1186/1471-2156-15-51

Published: 27 April 2014

Abstract

Background

Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population identified that common genetic variations located in 15q14 and 15q25 were associated with high myopia. To validate whether the same variations conferred risk to high myopia in the Han Chinese population, we genotyped 1,461 individuals (940 controls and 521 cases samples) recruited of Han Chinese origin.

Result

We found rs8027411 in 15q25 (P = 0.012 after correction, OR = 0.78) was significantly associated with high myopia but rs634990 in 15q14 (P = 0.54 after correction), OR = 0.88) was not.

Conclusions

Our findings supported that 15q25 is a susceptibility locus for high myopia, and gene RASGRF1 was possible to play a role in the pathology of high myopia.

Keywords:
RASGRF1 gene; High myopia; Refractive errors; Single nucleotide polymorphism; Correlation Analysis