Table 3

Generalized linear regression models showing the effects of genes on markers of insulin resistance/sensitivity
Non- diabetic Diabetic p interaction
Allele Phenotype Effects size 95% CI p Effects size 95% CI p
IRS1 A Fasting glucose 0.09 −0.11 to 0.30 0.372 −0.53 −2.96 to 1.90 0.668 0.330
2 h glucose 0.08 −0.36 to 0.51 0.723 2.33 −2.09 to 6.75 0.304 0.038
HbA1c 0.02 −0.10 to 0.14 0.746 0.13 −1.04 to 1.31 0.823 0.853
Fasting insulin −1.02 −3.76 to 1.71 0.463 −3.27 −20.75 to 14.21 0.714 0.690
2 h insulin 1.62 −15.50 to 18.75 0.853 2.36 −63.13 to 67.86 0.944 0.944
Glucose/insulin −0.14 −2.26 to 1.97 0.894 0.30 −8.40 to 9.00 0.946 0.896
HOMA-IR −0.22 −0.87 to 0.42 0.498 −2.03 −9.96 to 5.91 0.617 0.448
QUICKI 0.002 −0.015 to 0.018 0.857 −0.001 −0.025 to 0.022 0.903 0.877
FIRI −0.20 −0.78 to 0.38 0.480 −1.82 −8.97 to 5.31 0.617 0.448
PPARG C Fasting glucose −0.06 −0.26 to 0.13 0.528 0.003 −1.71 to 1.72 0.995 0.970
2 h glucose −0.02 −0.44 to 0.41 0.933 −2.46 −5.68 to 0.76 0.137 0.002
HbA1c 0.07 −0.04 to 0.19 0.216 −0.18 1.02 to 0.65 0.663 0.362
Fasting insulin −0.56 −3.21 to 2.09 0.617 −5.72 −18.00 to 6.57 0.363 0.283
2 h insulin 34.0 15.9 to 52.2 0.0003 −14.4 −64.7 to 35.8 0.575 0.017
Glucose/insulin −0.21 −2.26 to 1.83 0.840 −2.62 −8.82 to 3.37 0.407 0.307
HOMA-IR −0.12 0.74 to 0.51 0.714 −2.31 −7.89 to 3.27 0.417 0.299
QUICKI 0.0001 −0.015 to 0.016 0.924 −0.007 −0.024 to 0.009 0.377 0.481
FIRI −0.10 −0.67 to 0.46 0.714 −2.08 −7.10 to 2.94 0.417 0.299

Models are adjusted for age, sex and diabetes. FIRI, fasting insulin resistance index; HOMA-IR, homeostatic model assessment of insulin resistance; IRS1, Insulin Substrate Receptor 1; PPARG, Peroxisome Proliferator-Activated Receptor Gamma; QUICKI, the quantitative insulin-sensitivity check index.

Vergotine et al.

Vergotine et al. BMC Genetics 2014 15:10   doi:10.1186/1471-2156-15-10

Open Data