Table 3

False positive and true positive rates viaTotD|M, when v / μ is not known in advance, under expanding population (with correct r )
A. r=2.6 × 10-3
θμ σ=0 (neutral) σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.185 0.125 NA a NA
10-1/2 0.179 0.315 0.500 NA
1(=100) 0.095 0.184 0.352 0.600
10+1/2 0.056 0.141 0.340 0.580
10+1 0.018 0.058 0.283 0.551
B.r=4.0 × 10-3
θμ σ = 0 (neutral) σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.341 0.333 NA a NA
10-1/2 0.265 0.259 0.516 NA
1(=100) 0.187 0.258 0.509 0.886
10+1/2 0.081 0.210 0.491 0.818
10+1 0.026 0.115 0.408 0.668
C.r=5.7 × 10-3
θμ σ=0 (neutral) σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.372 0.583 0.833 NA a
10-1/2 0.288 0.376 0.680 NA
1(=100) 0.236 0.423 0.655 0.957
10+1/2 0.080 0.252 0.524 0.780
10+1 0.022 0.119 0.401 0.607

NOTE. Here, n=100, α = 1, and the backward/forward ratio v/μ=1 are fixed. The nominal significance level is set slightly above the relative frequency of TotD = 2 conditional on M=2. The tables show proportions of loci that tested positive via TotD|M out of those whose gene genealogies revealed recurrent mutations. θμ(≡ 4) is the rescaled forward mutation rate. σ(≡ 4Ns) denotes the rescaled selection coefficient. Here the null distributions are based on the correct recombination rate r (per generation).

a “NA” is assigned to a category with less than 10 loci with revealed recurrent mutations.

Ezawa et al.

Ezawa et al. BMC Genetics 2013 14:37   doi:10.1186/1471-2156-14-37

Open Data