Table 1

Relative expression patterns of GWAS diabetes genes in chow fed mice
Isl Brain Hypo P-AT BAT Liver SkM Hrt St SI LI Lung Kid Spl Ov Ut Thy
Adam30 NE Low NE Avg NE NE Avg Avg Avg NE NE NE NE Avg NE NE Avg
Adamts9 Low Low Avg Avg Avg Avg NE Avg Avg NE Avg Avg Avg Avg High High Avg
Camk1d Avg Avg Avg Avg Avg Avg Low Avg Avg NE High NE Avg Avg Avg Avg High
Cdc123 Avg Avg Avg Avg Avg Avg Low Avg Avg NE Avg Low Avg Avg High Avg Avg
Cdkal1 Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Low Avg Avg Avg Avg Avg
Cdkn2a (Arf) Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg Avg
Cdkn2a NE NE NE Avg Avg NE NE NE NE NE Avg NE Avg Avg NE NE Low
Cdkn2b High Avg Avg Avg Avg Avg NT Avg NT High NT NT Avg NT High Low Low
Ext2 Low Avg Avg Avg Avg Avg Low Avg Avg Avg Avg Low Avg Avg High Avg Avg
Hhex Low Avg Avg Avg Avg High Low Avg Low Low Avg Low Avg High Avg High Avg
Ide Avg Avg Avg Avg High Avg NT Avg NT Avg NT NT NT NT High Low Low
Jazf1 Avg Avg Avg Avg High NE NE Avg Low Low Avg Low Low Low Avg High Avg
Lgr5 NE High Avg Avg Low Avg Low Avg Avg NE Avg Low NE Avg High High Avg
Thada Avg Avg Avg Avg Avg Avg NE Avg Avg NE Avg Low Avg Avg High Avg Avg
Tspan8 Low Low Low Avg Avg Low Low Avg High NE High NE Avg High Avg High Low

Expression levels are relative within a gene, but comparisons between genes cannot be made. Isl = islets, Hypo = hypothalamus, P-AT = parametrial white adipose tissue, BAT = brown adipose tissue, SkM = skeletal muscle (soleus),Hrt = heart, St = stomach, SI = small intestine (duodenum), LI = large intestine (distal), Kid = kidney, Spl = spleen, Ov = ovary, Ut = uterus, Thy = thymus. NE = not expressed, Ct values within 2 cycles of negative control; avg. = average expression (within 5-fold (2.3 cycles) of average expression across all tissues); high = >5 fold higher (Ct values >2.3 cycles lower) than average expression; low = >5 fold lower (Ct value >2.3 cycles higher) than average expression. NT = not tested.

Ho et al.

Ho et al. BMC Genetics 2013 14:10   doi:10.1186/1471-2156-14-10

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