The EOB phenotype in woe2 mice. All woe2 neonates were born with bilateral open eyelids (B) in contrast to the WT neonates that have closed eyelids (A). Histological analysis of P0.5 woe2 mice confirmed the open eyelid phenotype and also revealed hyperkeratosis of the eyelids, stromal keratitis, absence of the conjunctival sacs, anterior synechiae, and hyperplastic corneas (D) features that were absent in the WT age matched controls (C). Further histological analysis of woe2 mice at E18.5 (F) showed failure of the embryonic eyelid closure (arrows) whereas WT controls exhibited embryonic eyelid closure (E).
Toonen et al. BMC Genetics 2012 13:76 doi:10.1186/1471-2156-13-76