(A) Cerebellar folia of four-week old Beagle puppy with NCCD. Loss of occasional Purkinje cells (grey arrows). The black arrow identifies a degenerating Purkinje cell with hypereosinophilic cytoplasm and a condensed nucleus. 100x magnification. (B). Cerebellar folia of eight-week old full-sibling Beagle puppy with NCCD. Marked loss of Purkinje cells (grey arrows). Associated granular cell layer depletion secondary to Purkinje cell loss (white double headed arrows). 100x magnification.
Forman et al. BMC Genetics 2012 13:55 doi:10.1186/1471-2156-13-55