Table 2

Suppressors of the caffeine sensitivity of mcm2AA
Gene ORF Function GO
srs2Δ YJL092C DNA repair, helicase 1
mcr1Δ YKL150W Oxidative stress response 1
tof1Δ YNL273W Subunit of fork pausing complex 1,2,5
rad9Δ YDR217C Transmission of checkpoint signal 1,2,4,56
rad2Δ YGR258C Nucleotide excision repair 1,4,6
pdr15Δ YDR406W Cellular detoxification 1,3
rds2Δ YPL133C Transcription factor 1,6,7
yhp1Δ YDR451C Transcription factor/cell cycle 2,4,6
mbp1Δ YDL056W Transcription factor/cell cycle 2,4,6
ume6Δ YDR207C Transcription factor 2,4,5,6
hrd1Δ YOL013C Ubiquitin ligase/ER assoc. decay 8
ssm4Δ YIL030C Ubiquitin ligase/ER assoc. decay 8
pac10Δ YGR078C Protein folding 8
sip18Δ YMR175W Osmotic stress 9
rpl8bΔ YLL045C Ribosomal protein 9
ett1Δ YOR051C Translation termination 9

Genes are grouped by their GO terms as annotated in the Saccharomyces cerevisiae database [37]. Horizontal lines separate different classes. Gene ontology: (1) Response to cell stress/chemical stimuli (2) cell cycle, (3) transport, (4) RNA metabolic process, (5) signalling process/protein modification process, (6) transcription, (7) carbohydrate metabolic process, (8) ER-mediated degradation & protein-folding and (9) other.

Stead et al.

Stead et al. BMC Genetics 2012 13:36   doi:10.1186/1471-2156-13-36

Open Data