Table 2

Summary of results across cohorts for four candidate genes identified through parallel analysis.

Gene

SNP

Quantitative Results

Qualitative Results

(LDL Cholesterol Traits)

(CAD, Atherosclerosis)


LDL-GENECARD

LDLP-CATHGEN

Fisher's Combined

GENECARD

CATHGEN

GENECARD Probands-CATHGEN Controls

Aortas

Linkage (LOD)

PPP2R2B

rs10037715

0.05

0.77

0.15

0.82

0.31

0.25

0.68

-17.8

rs2125443

0.38

0.001

0.01

0.71

0.31

0.84

0.13

-14.4

rs7736604

0.92

0.01

0.06

0.0003

0.22

0.45

0.02

-13.2

rs160974

0.92

0.62

0.62

0.47

0.004

0.50

0.65

-18.0

rs1383169

0.81

0.11

0.31

0.39

0.01

0.01

0.49

-9.3

rs1383167

0.99

0.28

0.63

0.45

0.08

0.92

0.02

-14.2

EBF1

rs17717527

0.01

0.73

0.05

0.40

0.55

0.13

0.31

-19.5

rs6865969

0.84

0.01

0.05

0.40

0.01

0.13

0.02

-20.0

rs4704963

0.78

0.24

0.51

0.03

0.67

0.38

0.46

-6.4

rs17712788

0.08

0.90

0.90

0.85

0.33

0.01

0.16

-8.3

SPOCK1

rs10054991

0.05

0.84

0.17

0.72

0.79

0.14

0.33

-14.8

rs17600115

0.33

0.003

0.001

0.85

0.27

0.43

0.05

-5.7

rs17170899

0.71

0.98

0.95

0.004

0.63

0.82

0.86

-1.6

rs6872714

0.19

0.80

0.44

0.91

0.02

0.64

0.04

-16.8

rs6884385

0.16

0.17

0.13

0.86

0.06

0.02

0.24

-16.0

rs2043478

0.88

0.77

0.94

0.49

0.33

0.23

0.01

-17.3

rs1919515

0.80

0.59

0.82

0.42

0.74

0.05

0.36

1.8

PRELID2

rs10074645

0.0002

0.71

0.001

0.93

0.67

0.19

0.66

-2.7

rs11950106

0.73

0.04

0.12

0.56

0.09

0.30

0.73

-13.7

rs7713855

0.93

0.54

0.85

0.77

0.003

0.13

0.33

-16.2

rs13179436

0.65

0.77

0.85

0.52

0.005

0.03

0.26

-16.0

rs443033

0.50

0.90

0.81

0.48

0.05

0.14

0.04

-10.1

rs7736046

0.98

0.80

0.98

0.86

0.03

0.81

0.19

2.1


P-values for the most significant results for SNPs for each analysis for the four top candidate genes (PPP2R2B, EBF1, SPOCK1, and PRELID2) are presented. The most significant result for each gene and analysis is in bold.

Nolan et al. BMC Genetics 2012 13:12   doi:10.1186/1471-2156-13-12

Open Data