Table 2 |
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|
Summary of results across cohorts for four candidate genes identified through parallel analysis. |
|||||||||
|
Gene |
SNP |
Quantitative Results |
Qualitative Results |
||||||
|
(LDL Cholesterol Traits) |
(CAD, Atherosclerosis) |
||||||||
|
|
|||||||||
|
LDL-GENECARD |
LDLP-CATHGEN |
Fisher's Combined |
GENECARD |
CATHGEN |
GENECARD Probands-CATHGEN Controls |
Aortas |
Linkage (LOD) |
||
|
PPP2R2B |
rs10037715 |
0.05 |
0.77 |
0.15 |
0.82 |
0.31 |
0.25 |
0.68 |
-17.8 |
|
rs2125443 |
0.38 |
0.001 |
0.01 |
0.71 |
0.31 |
0.84 |
0.13 |
-14.4 |
|
|
rs7736604 |
0.92 |
0.01 |
0.06 |
0.0003 |
0.22 |
0.45 |
0.02 |
-13.2 |
|
|
rs160974 |
0.92 |
0.62 |
0.62 |
0.47 |
0.004 |
0.50 |
0.65 |
-18.0 |
|
|
rs1383169 |
0.81 |
0.11 |
0.31 |
0.39 |
0.01 |
0.01 |
0.49 |
-9.3 |
|
|
rs1383167 |
0.99 |
0.28 |
0.63 |
0.45 |
0.08 |
0.92 |
0.02 |
-14.2 |
|
|
EBF1 |
rs17717527 |
0.01 |
0.73 |
0.05 |
0.40 |
0.55 |
0.13 |
0.31 |
-19.5 |
|
rs6865969 |
0.84 |
0.01 |
0.05 |
0.40 |
0.01 |
0.13 |
0.02 |
-20.0 |
|
|
rs4704963 |
0.78 |
0.24 |
0.51 |
0.03 |
0.67 |
0.38 |
0.46 |
-6.4 |
|
|
rs17712788 |
0.08 |
0.90 |
0.90 |
0.85 |
0.33 |
0.01 |
0.16 |
-8.3 |
|
|
SPOCK1 |
rs10054991 |
0.05 |
0.84 |
0.17 |
0.72 |
0.79 |
0.14 |
0.33 |
-14.8 |
|
rs17600115 |
0.33 |
0.003 |
0.001 |
0.85 |
0.27 |
0.43 |
0.05 |
-5.7 |
|
|
rs17170899 |
0.71 |
0.98 |
0.95 |
0.004 |
0.63 |
0.82 |
0.86 |
-1.6 |
|
|
rs6872714 |
0.19 |
0.80 |
0.44 |
0.91 |
0.02 |
0.64 |
0.04 |
-16.8 |
|
|
rs6884385 |
0.16 |
0.17 |
0.13 |
0.86 |
0.06 |
0.02 |
0.24 |
-16.0 |
|
|
rs2043478 |
0.88 |
0.77 |
0.94 |
0.49 |
0.33 |
0.23 |
0.01 |
-17.3 |
|
|
rs1919515 |
0.80 |
0.59 |
0.82 |
0.42 |
0.74 |
0.05 |
0.36 |
1.8 |
|
|
PRELID2 |
rs10074645 |
0.0002 |
0.71 |
0.001 |
0.93 |
0.67 |
0.19 |
0.66 |
-2.7 |
|
rs11950106 |
0.73 |
0.04 |
0.12 |
0.56 |
0.09 |
0.30 |
0.73 |
-13.7 |
|
|
rs7713855 |
0.93 |
0.54 |
0.85 |
0.77 |
0.003 |
0.13 |
0.33 |
-16.2 |
|
|
rs13179436 |
0.65 |
0.77 |
0.85 |
0.52 |
0.005 |
0.03 |
0.26 |
-16.0 |
|
|
rs443033 |
0.50 |
0.90 |
0.81 |
0.48 |
0.05 |
0.14 |
0.04 |
-10.1 |
|
|
rs7736046 |
0.98 |
0.80 |
0.98 |
0.86 |
0.03 |
0.81 |
0.19 |
2.1 |
|
|
|
|||||||||
|
P-values for the most significant results for SNPs for each analysis for the four top candidate genes (PPP2R2B, EBF1, SPOCK1, and PRELID2) are presented. The most significant result for each gene and analysis is in bold. |
|||||||||
|
Nolan et al. BMC Genetics 2012 13:12 doi:10.1186/1471-2156-13-12 |
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